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Thioridazine

An antipsychotic reserved for schizophrenia that has not responded to other antipsychotics.

Clinical information

Common uses

  • schizophrenia unresponsive to other antipsychotic drugs

Cautions

  • boxed warning: can dangerously disturb heart rhythm (sudden death reported)
  • last-line use only, after other antipsychotics fail
  • not for elderly people with dementia-related psychosis (higher death risk)
  • not with long QT syndrome or past heart rhythm problems

Interactions

  • fluoxetine, paroxetine (do not combine — raise its levels)
  • fluvoxamine (do not combine)
  • propranolol, pindolol (do not combine)
  • any other QT-prolonging medicine (do not combine)

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, thioridazine hydrochloride tablet label, setid 1fd16a99-e856-4a37-9dae-c443714fac14 (accessed 2026-08-16)

Approved brands & formulations6

Brand nameDosage formStrengthImporterCategory
MellerilTablet10 mgauthorized medicine importersPOM
MellerilTablet25 mgauthorized medicine importersPOM
ThioridazineTablet10 mg—POM
ThioridazineTablet25mg—POM
ThioridazineTablet50 mg—POM
ThiorilTablet10mgauthorized medicine importersPOM
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