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Tacrolimus

An immunosuppressant that prevents rejection of liver, kidney and heart transplants.

Clinical information

Common uses

  • preventing organ rejection after liver, kidney or heart transplant

Common side effects

  • tremor
  • high blood pressure
  • abnormal kidney function
  • high blood sugar or new diabetes
  • diarrhoea, constipation and headache

Cautions

  • boxed warning: higher risk of serious infections and cancers
  • can damage kidneys — blood levels monitored
  • can raise potassium levels
  • avoid live vaccines

Interactions

  • grapefruit juice and nelfinavir — avoid
  • CYP3A inhibitors — raise tacrolimus levels
  • CYP3A4 inducers — lower tacrolimus levels
  • mycophenolate — exposure can increase
  • cannabidiol — may raise tacrolimus levels
  • other kidney-toxic drugs, e.g. aminoglycosides, amphotericin B

Pregnancy: can harm the baby — discuss with your doctor

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, tacrolimus capsule label, setid 213f6047-f897-48a7-b78a-45d7124f2f16 (accessed 2026-08-16)

Approved brands & formulations16

Brand nameDosage formStrengthImporterCategory
PangrafCapsule0.5 mgauthorized medicine importersPOM
PangrafCapsule1 mgauthorized medicine importersPOM
TacrolimusParenteral ( Injection )5mg/mlPOM
TacrolimusCapsule0.25mgPOM
TacrolimusTopical Preparations ( Ointment )0.03% w/wPOM
TacrolimusCapsule0.5 mgPOM
TacrolimusCapsule5 mgPOM
TacrolimusCapsule1 mgPOM
TacrolimusTopical Preparations ( Ointment )0.1% w/wPOM
TacrolimusTablet2 mgPOM
Tacrolimus capsulesCapsule1mgState Trading Organization PlcPOM
Tacrolimus capsules USPCapsule0.5mgState Trading Organization PlcPOM
TacrozTopical Preparations ( Ointment )0.03% w/wauthorized medicine importersPOM
Tacroz™ Forte OintmentTopical Preparations ( Ointment )0.1 % w/w ( 10g )ADK Pharmaceutical Company Pvt. LtdPOM
Vitilimus 0.03%Topical Preparations ( Ointment )0.30 mg ( 30g )Meditime Pvt LtdPOM
Vitilimus 0.1%Topical Preparations ( Ointment )0.1% w/w ( 30g )Meditime Pvt LtdPOM
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