MedicinePOM

Selexipag

A tablet for pulmonary arterial hypertension that delays disease progression.

Clinical information

Common uses

pulmonary arterial hypertension (adults and children 2 and older)

Common side effects

headache
diarrhoea
jaw pain
feeling sick or vomiting
muscle or limb pain and flushing

Cautions

stop if pulmonary oedema from veno-occlusive disease is confirmed
avoid in severe liver impairment

Interactions

gemfibrozil (strong CYP2C8 inhibitor) — contraindicated
clopidogrel and other moderate CYP2C8 inhibitors — reduce to once daily
rifampin — dose may need doubling

Pregnancy: no well-controlled human studies — talk to your doctor

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, selexipag (Uptravi) label, setid a7a23b87-f892-4e2c-8e2e-ebf841220f90 (accessed 2026-08-16)

Approved brands & formulations1

Brand name	Dosage form	Strength	Importer	Category
Selexipag	Tablet	400mcg	—	POM