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Sacubitril + Valsartan

A combination heart failure medicine that lowers the risk of death and hospitalisation.

Clinical information

Common uses

  • chronic heart failure in adults
  • symptomatic heart failure in children 1 year and older

Common side effects

  • low blood pressure
  • high potassium
  • cough
  • dizziness
  • kidney problems

Cautions

  • must not be used in pregnancy — can injure the baby (boxed warning)
  • angioedema (severe swelling) can occur
  • never used with ACE inhibitors
  • kidney function and potassium need monitoring

Interactions

  • ACE inhibitors — contraindicated; wait 36 hours when switching
  • aliskiren in diabetes — contraindicated
  • potassium-sparing diuretics — raise potassium
  • NSAID painkillers — kidney risk
  • lithium — toxicity risk

Pregnancy: must not be used — can injure or kill the developing baby

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, sacubitril and valsartan tablet label, setid 3173e592-6f28-4864-9bf0-0ef0452da3de (accessed 2026-08-16)

Approved brands & formulations4

Brand nameDosage formStrengthImporterCategory
Entresto 100 mgTablet ( Film coated )48.6 mg + 51.4 mgADK Pharmaceutical Company Pvt. LtdPOM
Entresto 200 mgTablet ( Film coated )97 mg + 103 mgADK Pharmaceutical Company Pvt. LtdPOM
Entresto 50 mgTablet ( Film coated )24.3 mg + 25.7 mgADK Pharmaceutical Company Pvt. LtdPOM
Forhef 50Tablet ( Film coated )24mg + 26mgState Trading Organization PLCPOM
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