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MedicinerestrictedEssential

Quinine

An antimalarial capsule for uncomplicated falciparum malaria.

Clinical information

Common uses

  • uncomplicated falciparum malaria

Common side effects

  • cinchonism — headache, sweating, ringing in the ears
  • feeling sick, vomiting, diarrhoea
  • dizziness or vertigo
  • blurred vision

Cautions

  • never for leg cramps — life-threatening blood reactions (boxed warning)
  • not with long QT, G6PD deficiency, myasthenia gravis or optic neuritis
  • can cause low blood sugar, especially in pregnancy

Interactions

  • QT-prolonging drugs including some antiarrhythmics — avoid
  • other antimalarials like mefloquine or halofantrine — avoid
  • rifampin — treatment failures; avoid
  • digoxin — levels increase
  • CYP3A4 inhibitors or inducers — quinine levels change
  • neuromuscular blocking agents — avoid

Pregnancy: only if prescribed — untreated malaria is itself dangerous

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, quinine sulfate label, setid 1f32f05c-a215-40be-b951-e41a7b54a8a0 (accessed 2026-08-16)

Approved brands & formulations5

Brand nameDosage formStrengthImporterCategory
QuinineOral Liquid150mg/ml—restricted
QuinineTablet100mg—restricted
QuinineTablet300mg—restricted
Quinine DihydrochlorideParenteral ( Injection )80 mg/ml—hospital
Quinine DihydrochlorideParenteral ( Injection )600mg/3ml—hospital
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