MedicinePOM

Phentermine + Topiramate

A combination weight-loss capsule used with diet and exercise in obesity.

Clinical information

Common uses

weight loss in obesity
weight loss when overweight with a weight-related condition

Common side effects

tingling (paraesthesia)
dizziness
taste changes
trouble sleeping
constipation and dry mouth

Cautions

must not be used in pregnancy — causes birth defects
can trigger acute glaucoma — urgent review for eye pain or vision change
watch for depression or suicidal thoughts
may slow thinking — caution driving; do not stop suddenly

Interactions

MAOI antidepressants (contraindicated — hypertensive crisis)
alcohol and other sedatives
oral contraceptives (spotting possible)
non-potassium-sparing diuretics (low potassium)
valproic acid (high ammonia, low temperature)
other carbonic anhydrase inhibitors (acidosis, kidney stones)

Pregnancy: do not use — causes birth defects

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, phentermine and topiramate extended-release label, setid 260c3f90-163d-0bdd-1099-55d18a900e68 (accessed 2026-08-16)

Approved brands & formulations4

Brand name	Dosage form	Strength	Importer	Category
Phentermine + Topiramate	Capsule	11.25mg+69mg	—	POM
Phentermine + Topiramate	Capsule	3.75mg+23mg	—	POM
Phentermine + Topiramate	Capsule	15mg+92mg	—	POM
Phentermine + Topiramate	Capsule	7.5mg+46mg	—	POM