Clinical information
Common uses
- depression
- anxiety disorders, including panic disorder
- obsessive compulsive disorder (OCD)
- post-traumatic stress disorder (PTSD)
Common side effects
- feeling sick or being sick
- sexual problems, such as low sex drive
- feeling sleepy, dizzy or weak
- problems sleeping
- headaches
Cautions
- do not stop suddenly — withdrawal symptoms possible
- may not suit heart, liver or kidney problems, epilepsy, bleeding disorders
- do not drive if drowsy, dizzy or vision is blurred
- best not to drink alcohol while taking it
Interactions
- St John's wort (do not use)
- warfarin and other anticoagulants
- NSAIDs such as ibuprofen
- strong painkillers such as tramadol
- some other antidepressants
- tamoxifen (breast cancer medicine)
Pregnancy: can be used if needed — doctor will discuss risks and benefits
Reference information, not medical advice — always follow your doctor or pharmacist. Source: NHS Medicines A–Z, nhs.uk/medicines/paroxetine (accessed 2026-08-16)