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Methyldopa

A blood pressure-lowering medicine, long used including in pregnancy.

Clinical information

Common uses

  • high blood pressure

Common side effects

  • sedation, usually short-lived
  • headache
  • weakness

Cautions

  • can cause liver disorders — stop if fever or jaundice
  • can cause haemolytic anaemia (positive Coombs test)
  • periodic blood counts and liver tests needed
  • not with active liver disease

Interactions

  • MAOI antidepressants — do not combine
  • other blood pressure medicines — effect adds up
  • lithium — monitor for toxicity
  • iron salts (ferrous sulfate or gluconate) — avoid, reduce absorption
  • anaesthetics — doses may need reducing

Pregnancy: may be used — risk to the baby appears remote

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, methyldopa tablet label, setid 9e22e1d8-04ec-4b67-92ea-b09c706f2703 (accessed 2026-08-16)

Approved brands & formulations5

Brand nameDosage formStrengthImporterCategory
AldometTablet250 mgauthorized medicine importersPOM
DopatabTablet250 mgauthorized medicine importersPOM
Dopatab M250Tablet ( Film coated )250 mgHeart Land PharmacyPOM
MethyldopaTablet500mg—POM
MethyldopaTablet250 mg—POM
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