MedicinerestrictedEssential

Lopinavir/Ritonav

A combination HIV medicine (lopinavir with ritonavir, brand Kaletra) taken with other antiretrovirals.

Clinical information

Common uses

HIV-1 infection in adults
HIV-1 infection in children from 14 days old

Common side effects

diarrhoea
nausea
vomiting
raised triglycerides
raised cholesterol

Cautions

many serious drug interactions — check every new medicine
pancreatitis and liver damage, sometimes fatal, have occurred
can affect heart rhythm (QT and PR prolongation)
can trigger or worsen diabetes

Interactions

rifampin — do not combine
St John's wort — do not combine
simvastatin and lovastatin — do not combine
ergot medicines (ergotamine, dihydroergotamine) — do not combine
oral midazolam and triazolam — do not combine
hormonal contraceptives may work less well

Pregnancy: can be used with adjusted dosing — avoid the oral liquid

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, Kaletra (lopinavir and ritonavir) label, setid 8290add3-4449-4e58-6c97-8fe1eec972e3 (accessed 2026-08-16)

Approved brands & formulations4

Brand name	Dosage form	Strength	Importer	Category
Lopinavir/Ritonav	Tablet	100mg+25mg	—	restricted
Lopinavir/Ritonav	Tablet	200mg+50 mg	—	restricted
Lopinavir/Ritonav	Capsule	133.3mg+33.3mg	—	restricted
Lopinavir/Ritonav	Oral Liquid	400mg+100mg/5ml	—	restricted