MedicinePOMEssential

Lidocaine (Lignocaine) + Prilocaine

Lidocaine with prilocaine cream is a topical anaesthetic that numbs skin before procedures.

Clinical information

Common uses

numbing intact skin before procedures
numbing genital skin before minor surgery

Common side effects

temporary paleness where applied
redness
changes in temperature sensation
mild swelling
itching

Cautions

do not use more cream or longer than recommended
can rarely cause methaemoglobinaemia (blue-grey skin) — urgent help needed
extra care in babies and G6PD deficiency
must not reach the middle ear

Interactions

class III heart-rhythm medicines (amiodarone, sotalol) — extra monitoring
other lidocaine or prilocaine products (doses add up)
oxidising medicines (raise methaemoglobinaemia risk)

Pregnancy: only if clearly needed

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, lidocaine and prilocaine cream label, setid 69fed044-a6b8-40a7-9ba1-7fb10435ca74 (accessed 2026-08-16)

Approved brands & formulations2

Brand name	Dosage form	Strength	Importer	Category
Lidocaine (Lignocaine) + Prilocaine	Topical Preparations ( Cream )	25mg + 25mg/g	—	POM
Lidocaine (Lignocaine) + Prilocaine	Topical Preparations ( Cream )	0.05	—	POM