MedicinerestrictedEssential

Ledipasvir + Sofosbuvir

Ledipasvir with sofosbuvir (Harvoni) is a combination tablet that treats chronic hepatitis C.

Clinical information

Common uses

chronic hepatitis C (genotypes 1, 4, 5 or 6)
advanced cirrhosis or post-liver-transplant hepatitis C (with ribavirin)

Common side effects

tiredness
headache
weakness

Cautions

hepatitis B can reactivate — get tested before starting
dangerous slow heartbeat if taken with amiodarone
if combined with ribavirin, ribavirin's restrictions apply

Interactions

amiodarone (serious slow heartbeat; avoid)
rifampicin (avoid)
St John's wort (avoid)
carbamazepine, phenytoin or phenobarbital (reduce its effect)
antacids and acid-reducing medicines (separate doses; limit strength)
rosuvastatin (avoid — muscle damage risk)

Pregnancy: no human data; must avoid if combined with ribavirin

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, ledipasvir and sofosbuvir (Harvoni) label, setid 1a1c555d-2fdf-4150-8ace-dbc770c226bf (accessed 2026-08-16)

Approved brands & formulations1

Brand name	Dosage form	Strength	Importer	Category
Ledispavir + Sofosbuvir	Tablet	90mg + 400mg	—	restricted