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MedicinePOMEssential

Flucloxacillin

A penicillin antibiotic that treats skin, wound, bone and ear infections.

Clinical information

Common uses

  • skin and wound infections
  • bone infections (osteomyelitis)
  • ear infections

Common side effects

  • feeling or being sick
  • diarrhoea
  • bloating and indigestion

Cautions

  • not suitable if allergic to penicillin
  • tell your doctor about liver or kidney problems
  • take on an empty stomach
  • rare liver problems can appear up to 2 months after finishing

Interactions

  • methotrexate (arthritis medicine)
  • warfarin (blood thinner)
  • gout medicines probenecid and sulfinpyrazone
  • voriconazole (antifungal)
  • other antibiotics
  • oral typhoid vaccine (made less effective)

Pregnancy: safe to take in pregnancy

Reference information, not medical advice — always follow your doctor or pharmacist. Source: NHS Medicines A–Z, nhs.uk/medicines/flucloxacillin (accessed 2026-08-16)

Approved brands & formulations6

Brand nameDosage formStrengthImporterCategory
FlucloxacillinCapsule250mg—POM
FlucloxacillinTablet500mg—POM
FlucloxacillinCapsule500mg—POM
FlucloxacillinParenteral ( Injection )500mg—POM
FlucloxacillinTablet250mg—POM
FlucloxacillinOral Liquid125mg/5ml—POM
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