Clinical information
Common side effects
- feeling dizzy
- headaches
- difficulty sleeping
- cough
- feeling or being sick
Cautions
- can raise blood potassium — regular blood tests needed
- avoid salt substitutes and potassium supplements
- may not suit liver or kidney disease, or type 2 diabetes
- keep taking it even if you feel well
Interactions
- potassium-affecting drugs (spironolactone, amiloride, potassium supplements)
- blood pressure medicines (ramipril, losartan)
- antibiotics (clarithromycin, erythromycin, rifampicin)
- anti-inflammatory painkillers (ibuprofen, naproxen)
- lithium
- St John's wort
Pregnancy: occasionally prescribed — talk to your doctor
Reference information, not medical advice — always follow your doctor or pharmacist. Source: NHS Medicines A–Z, nhs.uk/medicines/eplerenone (accessed 2026-08-16)