MedicinePOM

Entrectinib

Targeted cancer capsule (kinase inhibitor) for certain lung cancers and solid tumours.

Clinical information

Common uses

ROS1-positive metastatic non-small cell lung cancer
NTRK gene fusion solid tumours

Common side effects

tiredness
constipation
taste changes
dizziness
nausea

Cautions

can cause heart failure — heart function checked
nervous-system effects: confusion, mood changes, sleep problems
risk of bone fractures and liver damage — regular blood tests
can harm an unborn baby

Interactions

strong or moderate CYP3A inhibitors (avoid or reduce dose)
CYP3A inducers (avoid)
drugs that prolong the QT heart interval (avoid)

Pregnancy: avoid — can harm an unborn baby

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, Rozlytrek (entrectinib) label, setid c7c71b0c-2549-4495-86b6-c2807fa54908 (accessed 2026-08-16)

Approved brands & formulations1

Brand name	Dosage form	Strength	Importer	Category
Entrectinib	Capsule	200mg	—	POM