MedicinePOMEssential

Duloxetine

Duloxetine is an SNRI antidepressant for depression, anxiety and nerve pain.

Clinical information

Common uses

depression and anxiety
nerve pain, including fibromyalgia
stress urinary incontinence in women

Common side effects

headaches
feeling or being sick
feeling dizzy or drowsy
dry mouth
diarrhoea, constipation or sleep problems

Cautions

may not suit epilepsy, heart disease or glaucoma
do not stop suddenly — withdrawal symptoms possible
serious risks include serotonin syndrome and suicidal thoughts
best not to drink alcohol

Interactions

MAOI antidepressants such as moclobemide and selegiline
warfarin, apixaban, clopidogrel (bleeding risk)
NSAIDs such as aspirin and ibuprofen
St John's wort — do not use

Pregnancy: can be used if needed — doctor weighs risks and benefits

Reference information, not medical advice — always follow your doctor or pharmacist. Source: NHS Medicines A–Z, nhs.uk/medicines/duloxetine (accessed 2026-08-16)

Approved brands & formulations5

Brand name	Dosage form	Strength	Importer	Category
Dulabid 20Mg Cap	Capsule	20mg	authorized importers after registration of the product	POM
Duloxetin	Capsule	30mg	—	POM
Duloxetine	Tablet	10 mg	—	POM
Duloxetine	Tablet	20 mg	—	POM
Duloxetine Hydrochloride	Capsule	20 mg	—	POM