MedicinePOM

Doxylamine Succinate + Pyridoxine

Doxylamine with pyridoxine (vitamin B6) treats nausea and vomiting of pregnancy.

Clinical information

Common uses

nausea and vomiting of pregnancy after conservative measures fail

Common side effects

sleepiness (somnolence)

Cautions

avoid driving or machinery until cleared by your provider
do not combine with alcohol or sedatives
caution with glaucoma, stomach ulcer or bladder obstruction
may interfere with urine drug screening tests

Interactions

MAOI antidepressants — contraindicated
alcohol (severe drowsiness)
sedatives and tranquilizers (severe drowsiness)

Pregnancy: intended for use in pregnancy; no increased birth defect risk reported

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, doxylamine succinate and pyridoxine hydrochloride label, setid 0c410285-0ad6-aabc-e063-6294a90abcd8 (accessed 2026-08-16)

Approved brands & formulations2

Brand name	Dosage form	Strength	Importer	Category
Doxinate	Tablet	10 mg+ 10 mg	authorized medicine importers	POM
Doxylamine Succinate + Pyridoxine	Tablet	10 mg+ 10 mg	—	POM