Medicinerestricted

Dolutegravir

Dolutegravir (Tivicay) is an integrase inhibitor used with other antiretrovirals to treat HIV-1.

Clinical information

Common uses

HIV-1 infection in adults and children (with other antiretrovirals)
two-drug regimen with rilpivirine in suppressed adults

Common side effects

insomnia
fatigue
headache

Cautions

stop immediately if signs of a hypersensitivity reaction
liver toxicity risk, higher with hepatitis B or C
never take with dofetilide

Interactions

dofetilide (heart rhythm drug) — contraindicated
antacids, laxatives, sucralfate (take dolutegravir 2 hours before)
calcium or iron supplements (separate doses unless taken with food)
carbamazepine, rifampin, efavirenz (need twice-daily dolutegravir)
St John's wort, phenytoin, phenobarbital (avoid)
metformin (levels increased)

Pregnancy: large studies show no increased birth defect risk

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, Tivicay (dolutegravir) label, setid 63df5af3-b8ac-4e76-9830-2dbb340af922 (accessed 2026-08-16)

Approved brands & formulations1

Brand name	Dosage form	Strength	Importer	Category
Dolutegravir	Tablet	50mg	—	restricted