MedicinePOMEssential

Conjugated estrogen

An estrogen hormone tablet used to treat menopause symptoms and prevent osteoporosis.

Clinical information

Common uses

moderate to severe hot flushes due to menopause
vaginal dryness and atrophy due to menopause
low estrogen from hypogonadism or ovarian failure
prevention of postmenopausal osteoporosis

Common side effects

stomach pain, back pain or headache
feeling sick and wind
breast pain
vaginal bleeding or discharge
trouble sleeping or low mood

Cautions

raises womb-cancer risk if used without a progestogen (boxed warning)
increased risk of stroke and blood clots; breast cancer with progestin (boxed warning)
not for preventing heart disease or dementia
use the lowest dose for the shortest time

Interactions

CYP3A4 inducers or inhibitors — may change estrogen levels

Pregnancy: not for use in pregnancy

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, PREMARIN (conjugated estrogens) tablets label, setid 258e1602-a3cf-4ccc-ca80-73dbbfb812ff (accessed 2026-08-16)

Approved brands & formulations2

Brand name	Dosage form	Strength	Importer	Category
Conjugated estrogen	Tablet	0.625mg	—	POM
Conjugated estrogen	Vaginal cream	0.625mg	—	POM