MedicinehospitalEssential

Caffein Citrate

Caffeine citrate is a medicine for apnoea of prematurity — pauses in breathing in premature babies.

Clinical information

Common uses

treatment of apnoea of prematurity

Common side effects

irritability, restlessness and jitteriness
fast heart rate
feeding intolerance
changes in blood sugar (high or low)
rash

Cautions

babies are monitored for necrotising enterocolitis, a serious bowel condition
blood caffeine levels may be monitored to avoid toxicity
baseline caffeine level checked if the baby had theophylline or the mother caffeine

Interactions

cimetidine and ketoconazole (slow caffeine removal)
phenobarbital and phenytoin (speed caffeine removal)
theophylline (concurrent use not recommended)
ketoprofen

Pregnancy: not applicable — given to premature babies

Reference information, not medical advice — always follow your doctor or pharmacist. Source: DailyMed, dailymed.nlm.nih.gov, Caffeine Citrate Injection/Oral Solution (Sagent) label, setid 5f38c395-0093-4afd-89ec-f96e5dc0934a (accessed 2026-08-16)

Approved brands & formulations4

Brand name	Dosage form	Strength	Importer	Category
AMEOCAFE	Oral liquid ( Solution )	20MG/ML USP	—	POM
Caffeine Citrate	Parenteral ( Injection )	20 mg/ml	MFDA designated importers with Pre Authorization approval before import	hospital
Caffeine Citrate	Parenteral ( Injection )	10 mg/ml	MFDA designated importers with Pre Authorization approval before import	hospital
Caffeine Citrate	Oral Liquid	20 mg/ml	—	POM